La ricerca è stata pubblicata dalla rivista Angewandte Chemie International Edition
Aids: farmaco modificato è molto più efficace
di oggisalute | 17 agosto 2012 | pubblicato in Ricerca
Con una piccola modifica un farmaco in studio per la lotta all’Hiv diventa 100 volte più efficace. Lo ha dimostrato uno studio del Politecnico di Monaco e dell’Università di Napoli pubblicato dalla rivista Angewandte Chemie International Edition. Differenti ceppi del virus Hiv possono usare due diversi recettori, chiamati Ccr5 e Cxcr4 per entrare nelle cellule del sistema immunitario.
I farmaci in uso fino a questo momento bloccano però solo l’entrata dei primi, mentre nessuno è in sperimentazione per i secondi. I ricercatori hanno preso un peptide sintetico, piccola proteina realizzata in laboratorio già conosciuta per le sue proprietà anti-Hiv, modificandola chimicamente in modo tale da ‘congelare’ una conformazione particolarmente favorevole.
Il peptide modificato ha mostrato un’affinità per i recettori Cxcr4 da 400 a 1500 volte maggiore di tutti i farmaci già conosciuti: “Siamo molto contenti per questo risultato – spiegano gli autori della ricerca, tra cui Luciana Marinelli e Sandro Cosconati dell’ateneo partenopeo – e ora non vediamo l’ora di passare ai test preclinici e clinici”.
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